Archives for August 15, 2016

Research Technology



There are now 14 federal agencies that will have representatives at the SBIR/STTR Road Tour event in St. Louis on August 18. Attendees can schedule one-on-one meetings with agency directors on a First Come- First Served basis. More than 70% of our current registrants are requesting one-on-one meetings – we anticipate that they will be totally full before the event. Time is of the essence!

  • Department of Agriculture (USDA)
  • Department of Commerce – National Institute of Standards and Technology
  • Department of Defense – Air Force
  • Department of Defense – Defense Advanced Research Projects Administration (DARPA)
  • Department of Defense – Missile Defense Agency (MDA)
  • Department of Defense – Navy
  • Department of Defense – Navy Naval Air Systems Command (NAVAIR)
  • Department of Energy (DOE)
  • Department of Health and Human Services – National Institutes of Health (NIH)
  • Environmental Protection Agency (EPA)
  • National Aeronautics and Space Administration (NASA)
  • National Science Foundation (NSF)
  • Small Business Administration (SBA)
  • United States Patent and Trademark Office (USPTO)

Examples of some Missouri companies that have received SBIR/STTR funding

This is an INCREDIBLY RARE opportunity for past and prospective applicants to learn more about the programs and increase the likelihood of their success. Please help us spread the word and encourage registration. Many thanks! Christy

SBIR/STTR Road Tour Registration Now Open! CET is proud to host the SBIR/STTR Road Tour on August 18, 2016 at Washington University-Simon Hall in partnership with BioSTL, Illinois Metro East Small Business Development Center at SIUE, MO PTAC St. Charles Eastern Region, MO Small Business Development & Technology Development Centers, MO S&T Technology Transfer & Economic Development St. Louis Economic Development Partnership, St. Louis Regional Chamber, St. Louis SBTDC/St. Louis Minority Business Council, Technology Entrepreneur Center/T-REX and the Skandalaris Center for Interdisciplinary Innovation and Entrepreneurship. The Road Tour is designed to help small businesses access the support and resources they need to understand SBIR/STTR funding opportunities. One-on-One meetings with agency directors are available on a first-come, first-served basis. Local applicants who have been successful in tapping this valuable funding resource will share their stories. Mark your calendar and check out the event website for more information

Twitter post with the attached image

Register now for #sbirroadtour in St. Louis August 18, 2016 at:

Share the recent Cortex blog post on the SBIR/STTR Road Tour

CHRISTY MAXFIELD, MBA, CFRE| CET Director of Entrepreneur Development Services

Cortex Innovation Community


20 South Sarah St.

St. Louis, Missouri  63108 USA


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F RoadTour Flyer SBIR STTR 8 18 16

Guide for Pedestrian and Bicycle Safety at Alternative Intersections and Interchanges (AII)

Announcement $400,000

New alternative intersection and interchange designs – including Diverging Diamond Interchanges (DDI), Displaced Left-Turn (DLT) or Continuous Flow Intersections (CFI), Restricted Crossing U-Turn (RCUT) intersections, Median U-Turn (MUT) intersections, Quadrant Roadway (QR) intersections – are being built in the United States. These designs may involve reversing traffic lanes from their traditional directions, which may introduce confusion and create safety issues for pedestrians and bicyclists. In addition, pedestrian paths and bicycle facilities may cross through islands or take different routes than expected. These new designs are likely to require additional information for drivers, cyclists, and pedestrians as well as better accommodations for pedestrians and bicyclists, including pedestrians with disabilities.
A central concern with alternative intersections is how to provide information to pedestrians, bicyclists, and drivers about the direction of car traffic, pedestrian crossing, and bicycle facilities particularly when those new intersection designs feature unfamiliar traffic flows and patterns. The concern is acute for visually impaired pedestrians, who require information about the alignment of crosswalks, signal controls, crossing times, direction of traffic, and direction through islands. Consistency in how information is provided is important as well; for example, various types of paths and lane markings are being used for bicyclists, with little information about the advantages and disadvantages of different strategies.

NSF: Integrated Earth Systems (IES)

see notice $1,000,000

Integrated Earth Systems (IES) is a program in the Division of Earth Sciences (EAR) that focuses on the continental, terrestrial and deep Earth subsystems of the whole Earth system. The overall goal of the program is to provide opportunity for collaborative, multidisciplinary research into the operation, dynamics and complexity of Earth systems at a budgetary scale between that of a typical project in the EAR Division’s disciplinary programs and larger scale initiatives at the Directorate or Foundation level. Specifically,IES will provide research opportunities for the study of Earth systems from the core of the Earth to the top of the critical zone with a specific focus on subsystems that include continental, terrestrial and deep Earth subsystems at all temporal and spatial scales (NROES, 2012). IES will provide opportunities to focus on Earth systems connected to topics which include (but are not limited to) the continents; the terrestrial, surficial Earth systems including physical, chemical and biotic dimensions; linkages among tectonics, climate, landscape change, topography and geochemical cycles including core and mantle processes.


The Commission on Enhancing National Cybersecurity, based at the National Institute of Standards and Technology (NIST) “requests information about current and future states of cybersecurity in the digital economy.” The 12-member panel is midway through five field hearings – it will be in Minneapolis August 23 – and is due to make detailed recommendations to President Obama in December on ways to strengthen cybersecurity in public and private spheres. These could be important. The group is chaired by Obama’s former National Security Adviser Thomas Donilon and includes University of Pittsburgh Chancellor Pat Gallagher (former NIST director); Annie Anton, chair of the School of Interactive Computing at Georgia Tech; Samuel J. Palmisano, former CEO of IBM, and Peter Lee, corporate VP, Microsoft Research. See the RFI.

Engineered Living Materials (ELM)

see notice

The Engineered Living Materials (ELM) program will develop design tools and methods that enable the engineering of structural features into cellular systems that function as living materials, thereby opening up a newdesign space for construction technology. These methods will be validated through the production of living materials that display hallmarks of biological systems, such as the ability to actively sense and respond to the environment, or to heal after damage. Successful completion of ELM program objectives will require innovations in the ability to functionally unite living components with inert structural materials, to program structural features into living systems, and to extend the scale of synthetic biology building blocks from the molecular to the cellular. The deliverables from this program will comprise a suite of technologies that enable the production of living structural materials tailored to design specifications, such as those provided by architects and builders.

The structural materials that are used to construct our homes, buildings, and infrastructure are expensive to produce and transport, are subject to damage due to environmental insults and aging, and have limited ability to respond to changes in the immediate surroundings. As a result, the energy and financial costs of building and infrastructure construction and repair, to both the DoD and the nation, are enormous. Living biological materials may have advantages over inert materials, in that they might be grown on-site from simple feed stocks under ambient conditions, self-repair when damaged, or respond to changes in their surroundings. The inclusion of living components in our built environments has obvious benefits; however, today we are unable to control the structural aspects (shapes and sizes) of living materials so that they can be useful for construction. The ELM program seeks to deliver technologies that will enable the addition of living structural materials into our built environments. Such novel materials would reduce the energy and financial burden associated with the manufacture and transport of materials to construction sites, since they will be able to grow on-site from natural feedstocks. Furthermore, as they will contain elements that are alive, the resulting structures will be endowed with the ability to self-repair and respond appropriately to changes in the environment.

A major inspiration for the ELM program is the recent development of biologically-sourced structural materials that are grown to specified size and shape from inexpensive feedstocks. For example, mycelia can be grown on agricultural byproducts to produce materials that are drop-in replacements for polystyrene. Similarly, bacteria can be used to bind sand to produce drop-in replacements for bricks. That factory-scale production of grown materials can be economically competitive with materials as common as polystyrene and brick, demonstrates the feasibility of using biological approaches to reduce the energy and waste associated with the manufacture of structural materials. However, as the final products are rendered inert during the manufacturing process, these early examples of grown materials retain few of the benefits of the biological components they contain; for example, the ability to respond to environmental cues or to selfrepair.

DARPA is seeking technologies that enable the engineering of hybrid materials composed of structural scaffolds that support the rapid growth and long-term viability of living cells that endow the final products with biological functions. These materials should exhibit aspects of both the inert grown materials that are being produced today at the factory scale, such as structural integrity, as well as those of living systems, such as self-repair. The platform technologies developed in the ELM program are intended to be scalable and generalizable, so as to be transitioned from the lab to industry in the near-term.

In addition, DARPA seeks the ability to engineer structural properties directly into the genomes of biological systems, so that living materials can be grown from progenitor cells (e.g., seeds), without the need of non-living scaffolds or external developmental cues. To address this goal, it will be necessary to program developmental pathways that result in multicellular systems with defined patterns and 3D shapes. The ability of multicellular organisms to develop and maintain defined body plans is evidence of the inherent potential of genetically-programmed biological structures. However, it is not yet possible to engineer these properties de novo. To enable genetic programming of multicellular morphology, synthetic biology will need to advance toward the engineering of multicellular systems derived from a single genotype. It is expected that successful proposers will not only create new advances in synthetic biology, but also leverage the state-ofthe- art in experimental and/or theoretical developmental biology.

Through ELM, DARPA seeks to cultivate foundational principles, as well as novel approaches and methods that will ultimately enable living structural materials with advanced capabilities to be rationally designed, and implemented through genetic engineering. DARPA has identified five fundamental capabilities that can conceivably be used in combination to enable the invention of a wide range of living materials of arbitrary form and function. The demonstration of these fundamental capabilities will form the major deliverables of the program, and are:
(1) on-site growth, maintenance, and reproduction of a living structural material on inexpensive feedstock;
(2) the precise coordination of cells and inert particles to form tunable multi-scale patterns;
(3) the ability to self-repair in response to damage;
(4) genetically programmed multicellular patterns; and
(5) genetically programmed multicellular 3D shapes.