Archives for August 27, 2015

Umit Koylu gets grant to commercialize fuel cell technology

Hydrogen Fuel News article spotlights Professor Umit Koylu’s latest in his long-term effort working with hydrogen as a fuel. The project itself is meant to commercialize the fuel cell technology developed by a research team lead by Ming Leu, a professor of integrated product manufacturing and mechanical and aerospace engineering. If successful, the project could be another victory for the overall fuel cell industry, which has been fighting for commercialization for more than a decade.

Umit Koyl;u

  Umit O. Koylu Professor Mechanical and Aerospace Engineering

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Ming Leu Director/Bailey Professor Mechanical and Aerospace Engineering

National Energetic Materials Consortium

Missouri S&T has joined a nascent group of universities and industries to look at energetic materials, their manufacture and the R&D to provide better effects, costs and safety.  Any faculty interested or with a contribution to share please contact Steve Tupper at OSP.

Updated Announcement Call NCEM_Page_1 Updated Announcement Call NCEM_Page_2

 

Traumatic Brain Injury Endpoints Development (TED) Initiative – Seed Project Awards

As of 2015, no drug has been approved by the US Food and Drug Administration (FDA) to treat traumatic brain injury (TBI). Decades of well-designed clinical trials have failed. The TED Initiative, funded by the Department of Defense, with support from a robust private-public partnership, is a 5-year direct collaboration between leading academic clinician-scientists, the FDA, industry leaders in biotechnology and imaging technology, philanthropies, and patient advocacy groups. Our ultimate goal is to advance the design of clinical trials that will lead to the first successful treatments of acute TBI.

Through early and iterative collaboration with FDA, TED’s overarching aims are to provide the field with a set of validated tools for TBI research; to precisely diagnose this multi-dimensional condition, to accurately stratify patients into trials based on characteristics of their injury, reliably measure the effects of injury over time, and to confirm that experimental drugs and devices are engaging their molecular target at the dose and schedule tested. Such tools will overcome the inherent limitations of the long-used symptom-based TBI classification approaches that divide patients into crude categories of mild, moderate, and severe, using the Glasgow Coma Scale (GCS); outcomes have traditionally been measured using the equally rudimentary Glasgow Outcome Scale-Extended (GOS-E). These measures do not permit mechanistic targeting for clinical trials or detection of differential effectiveness among TBI phenotypes. The GOS-E and GCS, along with head CT, are currently the only FDA-accepted tools for stratifying patients into TBI clinical trials and measuring outcomes.

The Seed Projects are designed to encourage investigators to identify and work toward validation of TBI COAs, blood-based biomarkers, and neuroimaging biomarkers using novel and traditional methodologies that will be presented to the FDA as validated endpoints and outcomes. These endpoints should support enrichment of patient selection/stratification for TBI clinical trials, and/or may serve as treatment endpoints. Seed projects must address the goals and bridge research gaps identified by the TED Steering Committee and its Government Steering Committee (GSC) . Seed Projects, in most cases, will focus on integrated and systematic analysis of the TED Metadataset for either: (i) existing clinical or imaging data, and/or (ii) collection of new data from existing biosamples. Applicants are encouraged to collaborate with private industry partners to leverage resources.

Projects should address one or more of the following goals:

A. Research to support TBI clinical outcome assessment tools that are suitable for use in clinical trials. Currently, almost all severe TBI therapeutic trials use incidents of adverse events (e.g., mortality) as a short-term outcome measure; the GOS, GOS-E, and Disability Rating Scale (DRS) are employed as long-term (3-6 month) primary endpoints for assessing drug efficacy. Most of these tools were developed for more severe forms of TBI, thus they may not be sufficiently sensitive to detect the diverse neurobehavioral deficits that can result from mild/moderate TBI. Validation of additional COAs could help enhance and improve these aspects of TBI clinical trials.

B. Research to support the use of TBI diagnostic biomarkers (blood-based and imaging) for patient stratification that are acceptable for use in therapeutic trials submitted to the FDA; to enrich for TBI populations that might be most responsive to treatment, to ultimately enhance and improve TBI therapeutic trials.

C. Research to support the use of TBI predictive biomarkers for patient stratification that are acceptable for use in therapeutic trials submitted to the FDA; to enrich for TBI patients that are likely to develop persistent post-concussive symptoms, to ultimately enhance and improve TBI therapeutic trials.

D. Research to support the use of pharmacodynamic biomarkers that are acceptable for use in therapeutic trials submitted to the FDA; to track whether therapeutic agents are effectively reaching their targets and exerting beneficial effects. The use of a TBI pharmacodynamic biomarker in conjunction with primary outcome data could provide more detailed insights as to why clinical efficacy is not demonstrated in subsets of subjects and help shed light on future improvements of drug trials of the same or related compounds.

NSF: Social Psychology

This program, offered by the U.S. National Science Foundation Division of Behavioral and Cognitive Sciences, supports basic research on human social behavior, including cultural differences, and development over thelife span. Among the many research topics supported are attitude formation and change, social cognition, personality processes, interpersonal relations and group processes, the self, emotion, social comparison and social influence, and the psychophysiological and neurophysiological bases of social behavior. Eligible institutions must be located in the USA. They include universities, government agencies and non-profit groups. U.S. commercial organizations, especially small businesses with strong capabilities in scientific or engineering research or education, are also encouraged to submit proposals. Scientists, engineers or educators in the USA and who are U.S. citizens may be eligible for support, if they are not employed by, or affiliated with, an organization. Annual target dates are January 15 and July 15, but proposals will be accepted on other dates.

Peace Scholars

The JR Program for International Peace awards scholarships to doctoral candidates at U.S. universities researching and writing dissertations with clear relevance for policy and practice in the field of internationalpeacebuilding and conflict management. Dissertation projects in all disciplines are welcome. Proposals should be consistent with the Institute’s mandate and present a research agenda with clear relevance to policy issues. Historical topics are appropriate if they promise to shed light on contemporary issues. Area studies projects and single case studies will be competitive if they focus on conflict and its resolution, apply to other regions and cases, or both. Peace Scholars carry out their fellowship work at their universities or other sites appropriate to their research. They are expected to devote full attention to their work and provide periodic reports to the Institute. Peace Scholars may be invited to give a presentation at the Institute and to participate in Institute workshops, conferences, and other activities. Citizens of any country may apply. Applicants must be enrolled in recognized doctoral programs (for example, Ph.D., S.J.D., Ed.D., Th.D.) in accredited universities in the United States. Successful candidates must have completed all course work and examinations towards their doctoral degrees by the time their fellowships begin. Each year the program awards approximately 10 Peace Scholar Fellowships. Awards are currently set at $20,000 for 10 months and are paid directly to the individual. Awards may not be deferred. They generally may not be combined with any other major award or fellowship except in special circumstances and with the written approval of the institute. The application deadline is Friday, December 11, 2015.

NIH – Biosafety

The Program invites applications for cooperative agreements to support the development and implementation of occupational safety and health and infection control training programs for workers who may be at risk during infectious disease outbreaks. The awarded programs will focus on dissemination of environmental infection control and hazard recognition training within a broad-set of occupational and community settings, including healthcare and non-healthcare job sectors. Awardees will identify target worker populations, environments or tasks that increase exposure to high risk such as Ebola Virus, that can be easily transmitted person-to-person and result in high mortality rates. Eligible organizations must be located in the US. They include higher education institutions and nonprofit groups. NIH intends to commit $3 million in FY 2016 for a total of $9 million over a period of 3 years to fund an estimate of 5 to 8 awards. Optional LOIs are due by September 21, 2015. Applications must be submitted by October 21, 2015.

Collaborative Activity Awards

James S. McDonnell Foundation offers Collaborative Activity Awards to initiate interdisciplinary discussions on problems or issues, to help launch interdisciplinary research networks, or to fund communities of researchers/practitioners dedicated to developing new methods, tools, and applications of basic research to applied problems. In each case the focus of the collaborative activity must meet the program guidelines for one of the following program areas:
– Studying Complex Systems
– Mathematical & Complex Systems Approaches for Brain Cancer
– Understanding Human Cognition

With the Collaborative Activity Awards, JSMF continues and formalizes a funding mechanism the Foundation has used since 1987. Over the past decade or so, the Foundation has from time to time provided grants to support study panels and research networks. This has proven to be an effective way to encourage cross-disciplinary thinking and research on fundamental questions. Furthermore, these activities have contributed to the development of programs both at the Foundation and at other funding agencies.

DOE Early Career Research Program

The Office of Science hereby invites grant applications for support under the Early Career Research Program in the following program areas: Advanced Scientific Computing Research (ASCR); Biological and Environmental Research (BER); Basic Energy Sciences (BES), Fusion Energy Sciences (FES); High Energy Physics (HEP), and Nuclear Physics (NP). The purpose of this program is to support the development of individual research programs of outstanding scientists early in their careers and to stimulate research careers in the areas supported by the DOE Office of Science.

Air Force Fiscal Year 2016 Young Investigator Research Program (YIP)

The Young Investigator Research Program (YIP) supports young scientists and engineers in Air Force relevant disciplines and is designed to promote innovative research in science and engineering. The awards foster creative basic research in science and engineering, enhance early career development of outstanding young investigators, and increase opportunities to recognize Air Force mission and challenges in science and engineering.

The objective of this program is to foster creative basic research in science and engineering, enhance early career development of outstanding young investigators, and increase opportunities for the young investigators to recognize the Air Force mission and the related challenges in science and engineering.

Flood damage after Katrina could have been prevented

eConnection’s Mary Helen Stoltz has published an article noting the work and opinions of Dave Rogers from the Department of Geosciences and Geological and Petroleum Engineering in Water Policy Law journal.

J. David Rogers, Ph.D., P.E., P.G., C.E.G., C.HG.. Karl F. Hasselmann Chair in Geological Engineering